Patients undergoing general anesthesia
Conditions
Interventions
Lidocaine (1.5 mg/kg) will be administered before rocuronium administration.
Placebo (same volume of saline) will be administered before rocuronium administration.
Sponsors
Kobe university
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients scheduled for general anesthesia. 2) Patients aged 50-79 years old. 3) Patients who agreed to a written informed consent.
Exclusion criteria
Exclusion criteria: 1) Patients with preoperative ALT > 100 U/L. 2) Patients with preoperative Cr > 1.5 mg/dL. 3) Patients with a history of neuromuscular disease. 4) Patients with drug sensitivity and allergy. 5) Patients with contraindications to lidocaine. 6) Patients using propranolol, amiodarone. 7) Patients who are judged to be inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Onset time (from the time of administration of rocuronium to maximum suppression of the twitch response) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) 50% depression time (from the time of administration of rocuronium to 50% suppression of the twitch response) 2) 100% depression time (from the time of administration of rocuronium to 100% suppression of the twitch response) 3) T1 recovery time (from the time of administration of rocuronium to recovery of the twitch response) | — |
Countries
Japan
Contacts
Public ContactShinya Taguchi
Kobe university graduate school of medicine Division of anesthesiology, Department of surgery related
Outcome results
None listed