A study to assess the effect of palonosetron in preventing propofol pain

A STUDY TO ASSESS THE EFFECT OF PRETREATMENT WITH INTRAVENOUS PALONOSETRON IN PREVENTING PAIN ON PROPOFOL INJECTION - A study to evaluate effect of intravenous palonosetron in preventing pain on propofol injection

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000050665

Enrollment

100

Registered

2023-03-23

Start date

2015-11-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ASA 1 and ASA 2 patients

Interventions

Group P - received palonosetron 0.075mg (2ml) intravenous route before propofol injection Group S - received normal saline (2ml) intravenous route

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patient who give written informed consent. Patients aged 18-60 yrs. Patients scheduled for elective surgery under general anaesthesia. Patients with ASA (American Society of Anaesthesiologists) grade I & II

Exclusion criteria

Exclusion criteria: Patients refusing to participate in the study. Patients inability to verbally express the severity of pain. Patients with ischemic heart disease, previous myocardial infarction, congestive heart failure, congenital long QT syndrome. Patients with electrolyte abnormalities. Patients with hepatic and renal dysfunction. Patients with chronic alcohol abuse and patients on antipsychotic drugs

Design outcomes

Primary

Measure	Time frame
To assess the effect of pre-treatment with intravenous palonosetron in preventing pain on propofol injection.	—

Secondary

Measure	Time frame
To evaluate the safety profile associated with the use of Palonosetron.	—

Countries

Asia(except Japan)

Contacts

Public ContactChaithali Hebri

Rajarajeswari Medical College and Hospital Department of Anaesthesiology

chaithali.hebri@gmail.com7975454808

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026