Prediction of postoperative effectiveness of epidural anesthesia in open liver/pancreatic surgery by using high frequency variability index (HFVI): prospective observational study

Prediction of postoperative effectiveness of epidural anesthesia in open liver/pancreatic surgery by using high frequency variability index (HFVI): prospective observational study - Prediction of postoperative effectiveness of epidural anesthesia in open liver/pancreatic surgery by using high frequency variability index (HFVI): prospective observational study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000050643

Enrollment

Registered

2023-03-22

Start date

2023-03-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who recieve open liver/pancreatic surgery

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The 52 adult patients who are scheduled to receive general anesthesia under intubation at our hospital and who meet all of the following criteria: 1) Patients undergoing open liver/pancreatic surgery under general anesthesia with epidural anesthesia at our hospital and scheduled to be admitted to our ICU after surgery. 2) Patient has ASA (American Society of Anesthesiologists) classification 1-3. 3) Written consent has been obtained

Exclusion criteria

Exclusion criteria: Exclude patients and timings with any of the following: 1) Under the age of 18 years old 2) Patients who are expected to be unable to respond to NRS due to severe dementia or sequelae of cerebral infarction 3) Patients with severe arrhythmia 4) Patients using beta-blockers before and during surgery 5) Immediately after using atropine 6) Use of sedatives such as dexmedetomidine after ICU admission 7) Respiratory rate less than 9 times/min 8) severe asthma 9) Skin disease on the anterior chest (where the sensor is attached)

Design outcomes

Primary

Measure	Time frame
The relationship between HFVI values at the end of surgery (just before awakening from general anesthesia) and maximum NRS (greater than/less than 3) from the end of surgery to the day after surgery.	—

Secondary

Measure	Time frame
The relationship between HFVI value immediately before extubation (before awakening from general anesthesia) after completion of surgery and morphine usage from the end of surgery to the next day of surgery. The relationship between the change in HFVI before and after regional anesthesia (initial local anesthesia via epidural catheter or nerve block after induction of general anesthesia) and the maximum NRS (greater than or less than 3) from the end of surgery to the next day after surgery. The relationshiip between HFVI values at the end of surgery and the incidence of delirium diagnosed by CAM-ICU (diagnostic tool for delirium in the ICU). The relationship between HFVI values immediately before extubation after surgery (before awakening from general anesthesia) and the incidence of PONV up to the day after surgery.	—

Measure

Time frame

The relationship between HFVI value immediately before extubation (before awakening from general anesthesia) after completion of surgery and morphine usage from the end of surgery to the next day of surgery. The relationship between the change in HFVI before and after regional anesthesia (initial local anesthesia via epidural catheter or nerve block after induction of general anesthesia) and the maximum NRS (greater than or less than 3) from the end of surgery to the next day after surgery. The relationshiip between HFVI values at the end of surgery and the incidence of delirium diagnosed by CAM-ICU (diagnostic tool for delirium in the ICU). The relationship between HFVI values immediately before extubation after surgery (before awakening from general anesthesia) and the incidence of PONV up to the day after surgery.

—

Countries

Japan

Contacts

Public ContactKeisuke Yoshida

Fukushima Medical University Department of Anesthesiology

kei-y7of@fmu.ac.jp0245471342

Outcome results