Patients undergoing general anesthesia
Conditions
Interventions
For general anaesthetics, the remimazolam is selected by the envelope method. Blood samples are taken at the time of appearance of PTC and TOF to determine the blood concentration of rocuronium.
For g
Sponsors
Nihon University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with American Society of Anesthesiologists physical status classification 1-3. After receiving written informed consent, patients aged twenty years old or more undergoing surgery with general anesthesia.
Exclusion criteria
Exclusion criteria: Patients with American Society of Anesthesiologists physical status classification 4 or more, patients with a history of allergic reaction to NMBAs, patients with hepatic disease, patients with neuromuscular disease, and patients who were receiving medication known to interfere with neuromuscular function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time from administration of rocuronium to first appearance of PTC response | — |
Secondary
| Measure | Time frame |
|---|---|
| The time from administration of rocuronium to TOFC0 (onset time), time from administration of rocuronium to first reappearance of TOFC1 (time to TOFC1), time from administration of rocuronium to first reappearance of TOFC2 (time to TOFC2), time from administration of sugammadex to TOF ratio 90% or higher, and blood concentration of rocuronium in the appearance of PTC and TOF. | — |
Countries
Japan
Contacts
Public ContactHanae Sato
Nihon University School of Medicine Department of Anesthesiology
Outcome results
None listed