Research on ingenious serial pancreatic juice aspiration cytological examination for abnormal pancreatic duct morphology and genetic analysis using pancreatic juice

Research on ingenious serial pancreatic juice aspiration cytological examination for abnormal pancreatic duct morphology and genetic analysis using pancreatic juice - Research on ingenious serial pancreatic juice aspiration cytological examination for abnormal pancreatic duct morphology and genetic analysis using pancreatic juice

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000050540

Enrollment

Registered

2023-03-10

Start date

2023-03-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

early-stage pancreatic cancer

Interventions

Scrape the mucosa of the gastrointestinal tract with a brush.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 18 years or older adults with pancreatic duct morphology abnormalities suspected of early pancreatic cancer and undergoing SPACE with ENPD tube placement under ERCP in Nagoya univercity hospital.

Exclusion criteria

Exclusion criteria: Patients who are deemed ineligible for participation in this study by the principal investigator or a principal study investigator Patients with difficulty in ENPD tube placement Patients after pancreatic surgery

Design outcomes

Primary

Measure	Time frame
Establish a method for evaluating pancreatic juice stored in the drainage bag by comparing the total pancreatic juice volume obtained from the ENPD tube and the number and quality of cells contained in it with the presence, type, and amount of cell-fixing solution or proteolytic enzyme inhibitor placed in the drainage bag.	—

Secondary

Measure	Time frame
Correlation between the degree of pancreatic endocrine function and/or evaluation of the pancreas by CT/MRI/ultrasound imaging and total pancreatic fluid volume obtained from the ENPD tube Changes in total pancreatic fluid volume and volume of pancreatic fluid obtained by aspiration before and after resumption of oral intake, and examination of the volume of pancreatic fluid submitted to cytological examination and the number and quality of cells contained in these samples. Contrasting mutant DNA, metabolites and proteins in pancreatic juice with final diagnosis and postoperative pathology specimens The extent of pancreatic duct morphology abnormalities, pH and/or temperature of the gastrointestinal wall and pancreatic juice, and comparison of the final diagnosis with breath hydrogen and microflora. Relationship between salivary and fecal microbiota, breath hydrogen and pancreatic duct morphology abnormalities, pancreatic exocrine function, and gastrointestinal mucosal microbiota. Identification of bacterial species specific to early-stage pancreatic cancer and their distribution in tissues by in situ hybridization The success rate of making organoids from pancreatic juice obtained from ENPD tubes, the relationship between morphology and expressed genes and final diagnosis, and the identification of factors involved in tumor growth.	—

Measure

Time frame

Correlation between the degree of pancreatic endocrine function and/or evaluation of the pancreas by CT/MRI/ultrasound imaging and total pancreatic fluid volume obtained from the ENPD tube Changes in total pancreatic fluid volume and volume of pancreatic fluid obtained by aspiration before and after resumption of oral intake, and examination of the volume of pancreatic fluid submitted to cytological examination and the number and quality of cells contained in these samples. Contrasting mutant DNA, metabolites and proteins in pancreatic juice with final diagnosis and postoperative pathology specimens The extent of pancreatic duct morphology abnormalities, pH and/or temperature of the gastrointestinal wall and pancreatic juice, and comparison of the final diagnosis with breath hydrogen and microflora. Relationship between salivary and fecal microbiota, breath hydrogen and pancreatic duct morphology abnormalities, pancreatic exocrine function, and gastrointestinal mucosal microbiota. Identification of bacterial species specific to early-stage pancreatic cancer and their distribution in tissues by in situ hybridization The success rate of making organoids from pancreatic juice obtained from ENPD tubes, the relationship between morphology and expressed genes and final diagnosis, and the identification of factors involved in tumor growth.

—

Countries

Japan

Contacts

Public ContactKentaro Yamao

Nagoya University Hospital Department of Endoscopy

k-yamao@med.nagoya-u.ac.jp+81-52-741-2111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026