Antimicrobial stewardship program in very preterm infants

The effectiveness and safety of implementation of a multi-disciplinary antimicrobial stewardship program in very preterm infants immediately after birth: a multicenter observational study in Japan - EOS study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000050532

Enrollment

564

Registered

2023-03-10

Start date

2023-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Very preterm infant

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Infants with a birth weight of less than 1500 grams or infants with a gestational age of less than 32 weeks 2. Infants who admitted within postnatal day 3

Exclusion criteria

Exclusion criteria: 1. Infant who admitted beyond postnatal day 3 2. Infant withhold resuscitation attempt because of lethal disease or death in delivery room

Design outcomes

Primary

Measure	Time frame
Efficacy: Days of antibiotics use beyond postnatal day7 Safety: Death during NICU stay	—

Secondary

Measure	Time frame
1.Early onset neonatal sepsis 2. Late onset neonatal sepsis NICU 3. Death during NICU stay/Late onset neonatal sepsis 4. Antibiotic consumption in NICU ward 5. The rate of proper antibiotic use beyond postnatal day 3 6. Prolonged antibiotic use (over 5 days without positive blood culture) 7. Resumption of antibiotics within 5 days after discontinuation of antibiotics 8. Acquisition of multidrug resistant organisms during NICU stay 9. Severe intraventricular hemorrhage/Necrotizing enterocolitis/focal intestinal perforation/chronic lung disease at 36 weeks postconceptional age 10. The period of NICU stay 11. The rate of EOS checklist use 12. Create team for antimicrobial steward ship in NICU 13. Create corporation with microbiological laboratory 14. Sharing the feedback information about institutional antibiotic consumption	—

Measure

Time frame

1.Early onset neonatal sepsis 2. Late onset neonatal sepsis NICU 3. Death during NICU stay/Late onset neonatal sepsis 4. Antibiotic consumption in NICU ward 5. The rate of proper antibiotic use beyond postnatal day 3 6. Prolonged antibiotic use (over 5 days without positive blood culture) 7. Resumption of antibiotics within 5 days after discontinuation of antibiotics 8. Acquisition of multidrug resistant organisms during NICU stay 9. Severe intraventricular hemorrhage/Necrotizing enterocolitis/focal intestinal perforation/chronic lung disease at 36 weeks postconceptional age 10. The period of NICU stay 11. The rate of EOS checklist use 12. Create team for antimicrobial steward ship in NICU 13. Create corporation with microbiological laboratory 14. Sharing the feedback information about institutional antibiotic consumption

—

Countries

Japan

Contacts

Public ContactDaisuke Kinoshita

Japanese Red Cross Kyoto Daiichi Hospital Division of Neonatology

daisuke-kinoshita@kyoto1.jrc.or.jp+81-75-561-1121

Outcome results