Prediction of therapeutic efficacy of ulcerative colitis based on gene expression in the colonic mucosa.

Study on the Efficacy of Remission Induction Therapy Based on Comprehensive Analysis of Colorectal Mucosa Gene Expression in Ulcerative Colitis - Comprehensive colorectal mucosal gene expression in ulcerative colitis and prediction of treatment response.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000050517

Enrollment

100

Registered

2023-04-01

Start date

2023-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ulcerative colitis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (i) Ulcerative colitis patients seen between May 1, 2023 and September 30, 2025 with a pMayo score of 6 or higher (ii) Patients who are able to obtain written consent for research participation of their own free will. (iii) Patients whose age at the time of consent is between 18 and 80 years old. (iv) Gender: any gender (v) Inpatient/outpatient: any

Exclusion criteria

Exclusion criteria: (i) Women who are pregnant or may become pregnant (ii) Patients after total colorectal resection (iii) Patients whom the attending physician deems inappropriate

Design outcomes

Primary

Measure	Time frame
Predicted effect of pre-treatment mucosal gene expression levels in subjects who achieved clinical remission/non-remission (defined as pMayo score <= 2) at week 16 after remission induction treatment	—

Secondary

Measure	Time frame
Comparison of pre-treatment gene expression by drug and effect used in remission induction therapy Comparison of pre-treatment mucosal metabolome expression by drug and effect of drugs used in remission induction therapy	—

Countries

Japan

Contacts

Public ContactKAZUHIKO UCHIYAMA

Kyoto Prefectural University of Medicine Molecular Gastroenterology and Hepatology

k-uchi@koto.kpu-m.ac.jp+81-05-251-5519

Outcome results