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Identification of fibrosis-promoting factors using magnetic resonance elastography (MRE) and proton density fat fraction (PDFF) in nonalcoholic fatty liver disease (NAFLD)

Identification of fibrosis-promoting factors using magnetic resonance elastography (MRE) and proton density fat fraction (PDFF) in nonalcoholic fatty liver disease (NAFLD) - Identification of Fibrosis-Promoting Factors in NAFLD

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000050414
Enrollment
500
Registered
2023-03-01
Start date
2023-02-17
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nonalcoholic fatty liver disease

Interventions

None listed

Sponsors

Nayoro City General Hospital Suita Municipal Hospital Tokyo Medical University Iwate Medical University Aichi Medical University of Medicine Osaka University Graduate School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (i) Patients with NAFLD for which viral, autoimmune, or alcoholic causes have been ruled out. (ii) Patients with MRE and MRI-PDFF taken more than 2 years after the first MRE and MRI-PDFF measurement. However, for patients with multiple MRE and MRI-PDFF imaging, the MRE and MRI-PDFF values after 2 years shall be used. For patients who are currently under observation and have not had MRE and MRI-PDFF after an interval of 2 years, MRE and MRI-PDFF will be newly obtained after obtaining consent. (iii) Patients whose participation is deemed appropriate by the principal investigator or subinvestigator. Translated with www.DeepL.com/Translator (free version)

Exclusion criteria

Exclusion criteria: (1) Patients with claustrophobia (2) Patients with magnetic materials or tattoos on the body (3) Patients with a pacemaker (3) Patients with a pacemaker (iv) Patients who are judged by the principal investigator or subinvestigator to be unsuitable for the study.

Design outcomes

Primary

MeasureTime frame
To clarify the relationship between the degree of hepatic steatosis and the rate of progression of liver fibrosis.

Countries

Japan

Contacts

Public ContactTakashi Kumada

Gifu Kyoritsu University Department of Nursing, Faculty of Nursing

takashi.kumada@gmail.com+819014740074

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026