Coagulation assessment of Antithrombin preparations in disseminated intravascular coagulation syndrome (DIC) associated with pneumonia.

Coagulation assessment of Antithrombin preparations in disseminated intravascular coagulation syndrome (DIC) associated with pneumonia. - Coagulation assessment of AT preparations in DIC associated pneumonia

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000050355

Enrollment

Registered

2023-02-16

Start date

2023-02-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1:Patients with sepsis due to pneumonia (including septic shock) and with an acute DIC criteria of at least 4 points. 2:Age is 20 years or older at the time of case registration. 3:AT activity level less than 70%. 4:Written informed consent has been obtained from the study subjects themselves or their surrogates.

Exclusion criteria

Exclusion criteria: 1:Patients with any of the following. (i) Complicated non-compensated liver cirrhosis with a Child-Pugh score of Grade B or above. (ii) Leukemia and related diseases. (iii) Patients with malignant tumors and receiving chemotherapy 2:Acute stage of trauma and burn injury 3:Patients receiving concomitant use of recombinant thrombomodulin 4:Patients on hemodialysis or extracorporeal circulation (CHDF, ECMO) 5:Research subjects who are judged by the principal investigator or physician in charge to be unsuitable for the safe conduct of this study.

Design outcomes

Primary

Measure	Time frame
Transition in coagulation fibrinolysis markers, inflammatory cytokines, vascular endothelial markers and AT during the first 5 days after administration of AT preparations	—

Countries

Japan

Contacts

Public ContactRyo Hisamune

Osaka Medical and Pharmaceutical University Department of Emergency and Critical Care Medicine

ryo.hisamune@ompu.ac.jp+81-72-683-1221

Outcome results