None (Healthy adults)
Conditions
Interventions
Amino acids (Period: 12 weeks)
Placebo (Period: 12 weeks)
Sponsors
KSO corporation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Subjects from 48 to 75 years of age at the time of obtaining consent to participate in this study. 2) Subjects whose MMSE-J score is 26 or higher, and MoCA-J score less than 30. 3) Subjects who have noticeable symptoms of memory loss or whose memory loss has been pointed out by others. 4) Subjects who can make self-judgment and provided written informed consent.
Exclusion criteria
Exclusion criteria: 1) Individuals who have a history of mental or cerebrovascular diseases. 2) CES-D score >= 16. 3) Individuals who use medicines which may affect central nervous system except for sleeping pills. 4) Individuals who regularly intake supplements or functional foods which may affect cognitive function. 5) Individuals who regularly intake supplements consisted of amino acids used in this study. 6) Individuals who have visual impairment or hearing impairment. 7) Individuals who are diagnosed with climacteric symptom or who have been treated with hormone replacement therapy. 8) Individuals who have a history of alcohol dependence. 9) Individuals who are under medical treatment of cancer or cirrhosis of liver. 10) Dialysis patients. 11) Individuals with phenylketonuria. 12) Blood donation within 4 weeks. 13) Individuals who have allergy of food provided on the day of assessment. 14) Individuals who participate or will participate in other clinical studies. 15) Individuals who are assessed to be inappropriate by the principal investigator due to other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| <Cognitive function> Battery Wechsler memory scale - revised Logical Memory I/II Figure Memory Visual Pared association I/II Verbal paired association I/II Visual reproduction I/II Trail Making Test, Part A & Part B(TMT-A,B) Verbal Fluency Task | — |
Secondary
| Measure | Time frame |
|---|---|
| JST-Index of Competence Pittsburgh Sleep Quality Index WHO-5-J SF-36v2 Standard Edition Questionnaire about subjective cognitive decline Amino acids and other metabolites | — |
Countries
Japan
Contacts
Public ContactYoshika Komori
KSO Corporation CEO
Outcome results
None listed