Association between cerebral blood flow and cognitive function in carotid endarterectomy

Association between changes in intracranial blood flow and higher brain function before and after carotid endarterectomy - Association between changes in intracranial blood flow and higher brain function before and after carotid endarterectomy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000050312

Enrollment

Registered

2023-02-12

Start date

2018-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

carotid artery stenosis

Interventions

near-infrared spectroscopy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Grade 1 or lower on the preoperative modified Rankin Scale (mRS) At least 1 month had passed from the last stroke or transient ischemic attack to carotid endarterectomy in the symptomatic case

Exclusion criteria

Exclusion criteria: Aphasia, apraxia, or agnosia Psychiatric diseases except mild cognitive impairment History of revascularization procedures including carotid endarterectomy

Design outcomes

Primary

Measure	Time frame
Changes in Mini-Mental state Examination (MMSE) score between before and 6-month after carotid endarterectomy surgery	—

Secondary

Measure	Time frame
Changes in Frontal Assessment Battery at bedside (FAB) score between before and 6-month after carotid endarterectomy surgery Changes in measurement value of near-infrared spectroscopy between before and 6-month after carotid endarterectomy surgery Changes of cerebral blood flow at rest between before and 6-month after carotid endarterectomy surgery Preoperative factors affecting MMSE score improvement from preoperative to 6 months	—

Measure

Time frame

Changes in Frontal Assessment Battery at bedside (FAB) score between before and 6-month after carotid endarterectomy surgery Changes in measurement value of near-infrared spectroscopy between before and 6-month after carotid endarterectomy surgery Changes of cerebral blood flow at rest between before and 6-month after carotid endarterectomy surgery Preoperative factors affecting MMSE score improvement from preoperative to 6 months

—

Countries

Japan

Contacts

Public ContactShunpei Andoh

Department of Neurosurgery (Omori), School of Medicine, Faculty of Medicine, Toho University Neurosurgery

s.andoh.ns@gmail.com03-3762-4151

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026