healthy subjects
Conditions
Interventions
Drink only sake in the first test, and after an interval of at least 1week, drink sake and water in the second test
Drink sake and water in the first test, and after an interval of at least 1 week, dr
Sponsors
Oita University
Sanwa Laboratory
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1) Japanese healthy male 2) BMI between 18 and 30 kg/m2 3) No abnormal findings on laboratory and physician's examination 4) ALDH2 *1/*1 genotype 5) having history of alcohol consumption over 100g without serious health problem 6) capable to understand the study's methods and compliance requirements, and give written informed consent to participate in this study of his own will
Exclusion criteria
Exclusion criteria: 1) having allergy or intolerance of alcohol 2) Existence or pre-existence of cardiovascular diseases 3) Existence or pre-existence of liver diseases 4) Existence or pre-existence of kidney diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| subject symptoms related to alcohol intoxication (VAS) psychomotor performance test (DSST) | — |
Secondary
| Measure | Time frame |
|---|---|
| pharmacokinetics of breath alcohol and acetaldehyde | — |
Countries
Japan
Contacts
Public ContactHiromitsu Imai
Oita University Dept of Medical Ethics, Faculty of Medicine
Outcome results
None listed