Helicobacter pylori-infected gastric cancer patients, Helicobacter pylori-infected gastritis patients, Helicobacter pylori non-infected patients
Conditions
Interventions
None listed
Sponsors
Tokai University
University of Shizuoka,School of Pharmaceutical Sciences Shizuoka Graduate University of Public Health National Institute of Public Health Keio University School of medicine Lithuanian University of Health Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: -Those who plan to undergo upper gastrointestinal endoscopy within 1 year from the date of consent to participate in this study -Subjects who have received a sufficient explanation about participating in this research and have obtained written consent of their own free will.
Exclusion criteria
Exclusion criteria: -Patients who regularly use PPI, PCAB, H2blocker as acid secretion inhibitors -Persons with high bleeding risk in histological examination -In addition, those who are judged inappropriate by the research director or co-investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To identify and compare changes in nutrients, metagenomic factors, metabolites, and microRNA molecules in gastric carcinogenesis by Helicobacter pylori, and to evaluate the interaction of these gastric microenvironmental factors. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) To examine changes in gastric microbiome and microRNA profiles in gastric cancer patients and compare these profiles between Lithuanian and Japanese gastric cancer patients. 2) Investigate changes in the amount of short-chain fatty acids in the gastric juice of gastric cancer patients, and compare the amounts with those of non-H. pylori-infected individuals. 3) Evaluate the relationship between the amount of short-chain fatty acids in gastric juice and nutritional factors, and compare the results between Lithuanian and Japanese subjects. 4) Quantify the expression of CD44v9 and CAPZA1 in gastric tissue and compare the differences in expression of these genes between Japanese and Lithuanian patients. 5) Investigate the subtype of CagA, the virulence factor of Helicobacter pylori, and compare between Japanese and Lithuanian. 6) To identify metagenomic and microRNA factors associated with gastric premalignancy (atrophic gastritis) and compare them between Japanese and Lithuanian subjects. | — |
Countries
Japan,Europe
Contacts
Public ContactHidekazu Suzuki
Tokai University School of Medicine Division of Gastroenterology and Hepatology Department of Internal Medicine
Outcome results
None listed