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Influence of the dual whitening on the whitening efficacy and tooth sensitivity

A clinical investigation of whitening efficacy and tooth sensitivity in a combined in-office and at-home whitening protocol - Clinical investigation of combined whitening

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000050164
Enrollment
90
Registered
2023-02-10
Start date
2021-11-16
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vital discolored tooth

Interventions

None listed

Sponsors

Nihon University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: All study participants gave their informed consent to take part in this study. The inclusion criteria for this study were the possession of six vital front teeth, first premolars, and second premolars in the upper jaw without caries lesions, restorations, large cracks, or tooth sensitivity. In addition, the patients had to be at least 18 years old with a maxillary anterior shade between A2 and A3.5 (VITA classical A1-D4 shade guide).

Exclusion criteria

Exclusion criteria: The exclusion criteria were allergy to hydrogen peroxide, periodontal disease, poor oral hygiene, ongoing treatment for a serious, systemic, and chronic disease, pregnancy or breastfeeding, previous whitening treatment, severe tetracycline-induced discoloration (Feinman classification 3 and 4) or fluorosis (Dean's index 3-5), and any other conditions deemed unsuitable by the supervising dentist.

Design outcomes

Primary

MeasureTime frame
The changes in tooth color were evaluated using a dental spectrophotometer before and after in-office whitening. A visual analog scale (VAS) was used to express the pain intensity when participants felt tooth sensitivity during and up to 24 h after whitening.

Countries

Japan

Contacts

Public ContactToshiki Takamizawa

Nihon University School of Dentistry Department of Operative Dentistry

takamizawa.toshiki@nihon-u.ac.jp0332198141

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026