Healthy subjects
Conditions
Interventions
Trigonelline low-dose group for 12 weeks
Trigonelline high-does group for 12 weeks
Placebo group for 12 weeks
Sponsors
University of Tsukuba
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Persons between the ages of 55 and 89 at the time the consent form is obtained. 2) Those who do not have a history of diabetes, cerebrovascular disease, cardiovascular disease, cancer, or paralysis (iii) Those who can drink coffee beverages (no allergies or rejection) (iv) Those who are able to discontinue the consumption of Sakurajima radish, hemp seed, oats, fenugreek, and shiso juice during the period of this study. (5) Those who are able to avoid eating potatoes, peas, perilla leaves, sea urchin, and jellyfish as much as possible during the period of this study. In addition, the subjects must be able to keep the upper limit of coffee intake other than that provided as the test food: 1 cup (200 ml) per day. (5) Those who have not participated or are not currently participating in any other clinical research within the past 3 months. (6) Those who fully understand the content of this study and are able to commute to the study site on their own.
Exclusion criteria
Exclusion criteria: Subjects with dementia (MMSE<-23 points) and depressions (GDS>-11 points). And/or are taking these medications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitrax | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood Concentration of Amyloid1-40 Blood Concentration of Amyloid1-42 Brain-derived neurotrophic factor "Trail making peg" test Geriatric Depression Scale Pittsburgh Sleep Quality Index Profile of Mood States 2nd Edition Physical Activity Scale for the Elderly SF8 Health Survey Body composition measured by bioelectrical impedance analysis | — |
Countries
Japan
Contacts
Public ContactTomohiro Okura
University of Tsukuba Faculty of Health and sport science
Outcome results
None listed