A multicenter observational study for measurement of SNPs in participants of the Japan Polyp Study Cohort

A multicenter observational study for measurement of SNPs in participants of the Japan Polyp Study Cohort - JPS Cohort SNP measurement study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000049978

Enrollment

1230

Registered

2023-01-10

Start date

2023-01-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Individuals who consented to participate in the JPS Cohort and have not withdrawn their consent.

Exclusion criteria

Exclusion criteria: non

Design outcomes

Primary

Measure	Time frame
Interaction between SNPs of ALDH2 and the effectiveness of aspirin in preventing the development of index lesions (ILs: cancers, adenomas with high-grade dysplasia, and adenomas measuring >= 10 mm) at 4 years	—

Secondary

Measure	Time frame
1) Interaction between SNPs of ADH1B and the effectiveness of aspirin in preventing the development of ILs at 4 years 2) Interaction between SNPs of CYP2A6 and the effectiveness of aspirin in preventing the development of ILs at 4 years 3) Impacts of SNPs of ALDH2, ADH1B, and CYP2A6 on the development of ILs and adenomas within the JPS Cohort 4) Interaction between SNPs of ALDH2 and the effectiveness of aspirin in preventing the development of adenomas at 4 years 5) Interaction between SNPs of ADH1B and the effectiveness of aspirin in preventing the development of adenomas at 4 years 6) Interaction between SNPs of CYP2A6 and the effectiveness of aspirin in preventing the development of adenomas at 4 years 7) Analyses of 1) to 6) taking into account the age, sex, alcohol intake, smoking, height, and body weight 8) Analyses of 1) to 6) using the site, size, and morphology of colorectal cancer as endpoints	—

Measure

Time frame

1) Interaction between SNPs of ADH1B and the effectiveness of aspirin in preventing the development of ILs at 4 years 2) Interaction between SNPs of CYP2A6 and the effectiveness of aspirin in preventing the development of ILs at 4 years 3) Impacts of SNPs of ALDH2, ADH1B, and CYP2A6 on the development of ILs and adenomas within the JPS Cohort 4) Interaction between SNPs of ALDH2 and the effectiveness of aspirin in preventing the development of adenomas at 4 years 5) Interaction between SNPs of ADH1B and the effectiveness of aspirin in preventing the development of adenomas at 4 years 6) Interaction between SNPs of CYP2A6 and the effectiveness of aspirin in preventing the development of adenomas at 4 years 7) Analyses of 1) to 6) taking into account the age, sex, alcohol intake, smoking, height, and body weight 8) Analyses of 1) to 6) using the site, size, and morphology of colorectal cancer as endpoints

—

Countries

Japan

Contacts

Public ContactNozomu Kobayashi

National Cancer Center Hospital Cancer Screening Center/ Endoscopy Division

nokobaya@ncc.go.jp0335422511

Outcome results