Advanced glycation end-products
Conditions
Interventions
Hydrogen-releasing supplements for 20 weeks or Reduced form of CoQ10 for 20 weeks or Foods containing Salacia ingredients for 20 weeks or Foods containing mulberry leaf ingredients for 20 weeks or
Sponsors
Okayama University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Those who have at least 1 S.D. above the mean SAF for the subject's age at the time of screening prior to obtaining consent 2. Those who are 20 years-old or older at the time of obtaining consent 3. Those who have given their free written consent after receiving sufficient explanation for participation in this research
Exclusion criteria
Exclusion criteria: 1. Those who are below the SAF average for the subject's age, or those who are above the average but below 1 S.D. at the time of screening prior to obtaining consent 2. Those who have a SAF value variation of more than plus/minus 0.2 a.u. from the SAF value at screening during the previous observation period 3. Those who are 70 years-old or older, BMI 30 or higher, and current smoker at the time of consent 4. Those who suspected alcohol or caffeine addiction 5. Those who with extremely irregular lifestyle 6. Those who have history of cardiovascular disease (males only), diabetes mellitus, or renal failure (on dialysis) 7. Patients with severe renal disease (more than BUN 25 mg/dL or serum creatinine 2.0 mg/dL) 8. Patients with severe liver disease (more than AST (GOT) or ALT (GPT) 100 U) 9. Pregnant or possibly pregnant or lactating women 10. Those who are drug addiction 11. Individuals who are deemed inappropriate as research participants by the principal investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of the difference between the mean SAF at the end of the last week (week 20) of supplementation and the mean SAF during the previous observation period (1-2 weeks) in individual subjects | — |
Countries
Japan
Contacts
Public ContactNoritaka Ariyoshi
Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
Outcome results
None listed