Adult
Conditions
Interventions
Apply test cosmetics (cream) to the designated left or right half face during 12 weeks.
Apply placebo cosmetics (cream) to the designated left or right half face during 12 weeks.
Sponsors
Yamada Bee Company, Inc.
Research Center for Immunological Analysis, Inc.
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1) Subjects who feel skin aging(wrinkle, elasticity, sagging). 2) Japanese females aged 40-60 years. 3) Subjects can understand and comply with the rules written in protocol during clinical study period. 4) Subjects whose written informed consent has been obtained.
Exclusion criteria
Exclusion criteria: The following exclusion criteria apply to subjects. 1) Constantly use cosmetic that contain the ingredient involved in this study. 2) With cosmetic allergies. 3) Visit dermatology department(for the purpose of treating atopic dermatitis etc.). 4) With inflamed or scraped skin on the measuring area. 5) Conducting hormone replacement therapy. 6) Have got cosmetic surgery which would affect the measuring area. 7) Will get sunburned during the test period. 8) Will receive special treatment (facial esthetics, epilation etc.) during the test period. 9) Can not maintain regular lifestyle. 10) Have an irregular habit because of working at night or working under work-shift form. 11) Drinks more than 500 mL beer daily. 12) A smoker. 13) Participated in other clinical trial within last 3 months. 14) Working at the health food, cosmetics or pharmaceutical company. 15) Constantly use cosmetic, quasi-drugs, healthy foods that may affect the test. 16) Judged not appropriate by principal.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wrinkle evaluation using the replica of eye corner[Max. depth biggest wrinkle] | — |
Secondary
| Measure | Time frame |
|---|---|
| Wrinkle grade evaluated using a picture of eye corner Wrinkle evaluation using the replica of eye corner Skin questionnaire VISIA's indicators Skin replica analysis (texture) Skin thickness Moisture and NMF in skin Water content of stratum corneum Stratum corneum tape stripping Skin elasticity Transepidermal water loss Skin microbiota | — |
Countries
Japan
Contacts
Public ContactShiho Ikegami
Yamada Bee Company, Inc. Functional Ingredient research section, Institute for Bee Products & Health Science, R&D department
Outcome results
None listed