Resectable pancreatic cancer
Conditions
Interventions
Treatment with chemotherapy and hyperbaric oxygen therapy
Chemotherapy: 2 courses S-1 40 mg/m2 twice a day for 14 days followed by a 7 days rest + Gemcitabine 1,000mg/m2 on days 1 and day 8 every 3 weeks Hyperbaric oxygen therapy : A total of 4 times
Sponsors
Division of Surgery National Hospital Organization Higashi-Ohmi General Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) invasive ductal carcinoma of the pancreas 2) resectable pancreatic cancer at diagnosis 3) no distant metastasis 4) R0/1 resectable 5) Negative cytology of washed ascites by staging laparotomy or PET-CT 6) all adult who anticipate to undergo pancreatectomy 7) no prior therapy 8) written informed consent
Exclusion criteria
Exclusion criteria: 1) pulmonary fibrosis or interstitial pneumonitis 2) frequent watery diarrhea that is resistant to treatment 3) active double cancer 4) distant metastasis 5) R2 resection 6) prior anti-cnacer therapy 7) pregnancy 8) a history of spontaneous pneumothorax, bronchial asthma, open-heart surgery, etc., and who are at risk of acute ventilation failure 9) ophthalmic treatment/after surgery (when intraocular pressure gas C3F8, SF6 is used for retinal detachment, etc.) 10) Difficult to tolerate radical surgery 11) Have an active infectious disease (fever 38.0 degrees or higher) 12) those who do not have sufficient judgment to obtain consent for this research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1 year relapse-free survival | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse effect Dose intensity Resectability rate Pathological effect Tumor marker Tumor volume Form of recurrence | — |
Countries
Japan
Contacts
Public ContactHiroya Akabori
National Hospital Organization Higashi-Ohmi General Medical Center Division of Surgery
Outcome results
None listed