ovarian carcinoma, tubal carcinoma, peritoneal carcinoma
Conditions
Interventions
None listed
Sponsors
The Jikei University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: (1) Patients with histopathologically diagnosed ovarian cancer, fallopian tube cancer, or peritoneal cancer. (2) Patients diagnosed as advanced stage III or IV by initial surgery (diagnostic laparoscopy or laparotomy), CT or MRI scan, and judged to be unable to undergo primary debulking surgery. (3) Patients with evaluable lesions (4) Age between 18 and 80 years old (5) PS (ECOG) 0 or 1 (6) Patients who have given written informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with contraindications to either paclitaxel or carboplatin. (2) Patients with poorly controlled cardiac disease, renal disease, or diabetes mellitus. (3) Patients with interstitial pneumonia or pulmonary fibrosis (to be confirmed by CT scan). (4) Patients with intestinal paralysis or intestinal obstruction that is poorly controlled. (5) Patients with infectious diseases requiring treatment. (6) Patients with a history of radiation therapy to the chest or abdomen. (7) Patients with active multiple cancers (not including intraepithelial cancer). (viii) Patients with a history of serious drug hypersensitivity. (9) Patients with symptomatic central nervous system metastasis. (10) Patients who are pregnant or lactating. (11) Patients who are currently receiving or have recently received other investigational drugs (including unapproved drugs). (12) Patients who are judged to be inappropriate to participate in this study by the investigators or co-investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage change in GIS score with preoperative chemotherapy | — |
Secondary
| Measure | Time frame |
|---|---|
| Response rate to chemotherapy before IDS | — |
Countries
Japan
Contacts
Public ContactNozomu Yanaihara
The Jikei University Obstetrics and Gynecology
Outcome results
None listed