Study to reduce the oocyte degeneration rate in oocytes with low oolemma extensibility during ICSI by re-puncture the oocyte from another site.

Prospective randomized controlled study on the effect of multiple punctures on oocytes with low oolemma extensibility during ICSI - Investigation of the effect of multiple punctures during ICSI

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000049763

Enrollment

400

Registered

2022-12-23

Start date

2023-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male infertility and failure to fertilize during in vitro fertilization

Interventions

If the oolemma extension is low when the pipette is punctured during ICSI, re-puncture from a different site. Perform ICSI without re-puncture.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with male infertility (oligospermia, teratozoospermia) or previous in vitro fertilization failure who are candidates for ICSI. Patients who have given written consent to participate in this study.

Exclusion criteria

Exclusion criteria: Patients who are eligible for TESE or PESA. Patients with low fertilization rate by previous ICSI, or patients with severe oligozoospermia or teratozoospermia, who are indicated for oocyte activation. Patients who cannot give written consent to participate in this study.

Design outcomes

Primary

Measure	Time frame
Oocyte degeneration rate after ICSI	—

Secondary

Measure	Time frame
Fertilization rate, blastocyst development rate, pregnancy rate, miscarriage rate	—

Countries

Japan

Contacts

Public ContactShinichi Watanabe

Sawada Women's Clinic IVF Lab.

shinwind@mail.goo.ne.jp0527883588

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026