Comparison of postoperative nausea and vomiting between general anesthesia with remimazolam and general anesthesia with propofol: A randomized non-inferiority trial.

Comparison of postoperative nausea and vomiting between general anesthesia with remimazolam and general anesthesia with propofol: A randomized non-inferiority trial. - Comparison of postoperative nausea and vomiting between general anesthesia with remimazolam and general anesthesia with propofol: A randomized non-inferiority trial.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000049707

Enrollment

110

Registered

2022-12-06

Start date

2023-05-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing surgery under general anesthesia who do not receive postoperative opioids by epidural analgesia nor intravenous PCA.

Interventions

remimazolam-based total intravenous anesthesia propofol-based total intravenous anesthesia

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists(ASA) physical status of I-III.

Exclusion criteria

Exclusion criteria: Patients with severe cardiac, renal, or hepatic dysfunction, severe anemia, and allergies to remimazolam or propofol.

Design outcomes

Primary

Measure	Time frame
the incidence of postoperative nausea and vomiting for 3 hours and 24 hours after the surgery.	—

Secondary

Measure	Time frame
rescue antiemetic use, severity of nausea ,timing of onset of PONV	—

Countries

Japan

Contacts

Public ContactHiroshi Yamashita

Kobe city medical center general hospital department of anesthesiology

cantateveritas@kcho.jp0783024321

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026