Healthy Japanese subjects
Conditions
Interventions
Duration: Four weeks Test product: Mouthwash (containing 0.005% hypochlorous acid) Administration: On the day of screening (before using test product
Scr), after each pre-use measurement, rinse your mouth with approximately 20 ml of test product for approximately 20 seconds and spit it out. After that, receive each measurement again. After the sta
Sponsors
ORTHOMEDICO Inc.
Medical Corporation Seishinkai, Takara Clinic Nerima Medical Association, Minami-machi Clinic Medical Corporation Yuseikai, Horiuchi Dental Clinic
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Japanese 2. Men or women 3. Adults 4. Healthy subjects 5. Subjects who are concerned about their halitosis 6. Subjects will be selected based on the results of halitosis measurement at Scr
Exclusion criteria
Exclusion criteria: Subjects who 1. are undergoing medical treatment or have a medical history of malignant tumor, heart failure, and myocardial infarction 2. have a pacemaker or an implantable cardioverter defibrillator (ICD) 3. are currently undergoing treatment for any of the following chronic diseases: cardiac arrhythmia, liver disorder, kidney disorder, cerebrovascular disorder, rheumatism, diabetes mellitus, dyslipidemia, hypertension, or any other chronic diseases 4. use or take "Foods for Specified Health Uses," or "Foods with Functional Claims" in daily 5. are currently taking medications (including herbal medicines) and supplements 6. are allergic to medicines and/or the test food related products 7. show allergic reactions to hypochlorous acid 8. are pregnant, lactating, or planning to become pregnant during this trial 9. suffer from COVID-19 10. have been enrolled in other clinical trials within the last 28 days before the agreement to participate in this trial or plan to participate another trial during this trial 11. are judged as ineligible to participate in this study by the physician 12. take functional food/beverage to improve halitosis 13. use artificial tooth, post crowns, dentures, implants or bridges 14. regularly use gargle medicine, medicated toothpaste, floss, interdental brush, and mouthwash 15. have a medical history or current history of Sjogren's syndrome, or who are suspected it 16. have diseases associated with salivary gland such as dry mouse and salivary stone disease 17. are undergoing medical treatment for periodontosis or dental caries 18. are dental treatment or have dental diseases 19. are smokers, or started smoking cessation within one year before the agreement to participate in this trial 20. plan to receive dental maintenance care (such as removing dental plaque) at the dental clinic during this trial 21. are more likely to get stomatitis 22. cannot brush their teeth three times a day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. B/B value | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Amount of adenosine triphosphate (ATP) in saliva | — |
Countries
Japan
Contacts
Public ContactNaoko Suzuki
ORTHOMEDICO Inc. R&D Department
Outcome results
None listed