healthy adults
Conditions
Interventions
24-hour continuous blood collection, 24-hour constant routine protocol (sustained wakefulness, constant postural maintenance, distributed food intake)
Sponsors
National Center of Neurology and Psychiatry
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Males aged 20 to 29 years old or aged 60 to 79 years old
Exclusion criteria
Exclusion criteria: 1) Those who have difficulty in blood sampling due to alcohol allergy or vasovagal reflex. 2) Those who have difficulty staying in the laboratory 3) Those who have sleep problems deviating from normal aging changes based on polysomnography, questionnaires, sleep diaries, and actigraphy 4) Those who are taking or have a history of pre-existing medical conditions (cardiovascular, liver, endocrine, brain/neurological, and psychiatric) or therapeutic medications that may affect the outcomes 5) Those who are dependent on alcohol or who have the habit of excessive alcohol consumption 6) Those who have a habit of taking drugs or supplements that affect sleep 7) Those who have experienced across time-zones or shift work at least 6 months prior to the study. 8) Other persons deemed inappropriate by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A set of molecules in the exosome whose rhythms become abnormal with aging | — |
Secondary
| Measure | Time frame |
|---|---|
| sleep habits (sleep diary, questionnaire, actigraphy), sleepiness(wake EEG, subjective ratings), cognitive behavioral functions(test battery), salivary melatonin rhythms, body temperature rhythms | — |
Countries
Japan
Contacts
Public ContactShingo Kitamura
National Center of Neurology and Psychiatry Department of Sleep-Wake Disorders
Outcome results
None listed