Analysis of microbiota in tissue samples obtained by endoscopic ultrasonography-guided fine needle biopsy

Analysis of microbiota in tissue samples obtained by endoscopic ultrasonography-guided fine needle biopsy - Analysis of microbiota in tissue samples obtained by endoscopic ultrasonography-guided fine needle biopsy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000049543

Enrollment

100

Registered

2022-11-17

Start date

2022-11-17

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatobiliary and Pancreatic Diseases

Interventions

Scrape the mucosa of the gastrointestinal tract with a brush.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Among adults over 20 years of age undergoing endoscopic ultrasonography-guided fine needle biopsy (EUS-FNB) for mass lesions of the liver, biliary tract, or pancreas, those who understand the contents of this study and have given written consent to participate in the study are eligible.

Exclusion criteria

Exclusion criteria: Patients who wish to be excluded from the study If the principal investigator or sub-investigator determines that the patient is ineligible to participate in the study for any other reason.

Design outcomes

Primary

Measure	Time frame
Identification of tissue microbiota specific to various hepatobiliary and pancreatic diseases	—

Secondary

Measure	Time frame
Success rate of bacterial detection in tissues obtained by EUS-FNB Evaluation of the required sample volume, including area measurement, length, and cell count of EUS-FNB specimens for detection of microbiota by stereomicroscopic observation Association of bacteria flora with pancreatic duct and bile duct stenosis Identification of bacteria or bacterial genes associated with background pancreatic diseases (chronic pancreatic disease, pancreatic lipidosis, pancreatitis, etc.) diagnosed by CT/MRI or biopsy Relationships between other tissues (saliva, feces, intestinal mucosa, digestive juices) and microbiota and diversity in pancreatic tissues. Assessment of the relationship between progression and bacterial flora/diversity in malignant tumors Evaluation of the relationship between response to therapy and microbiota/diversity. Short-term/long-term prognosis and bacterial flora/diversity Assessment of the association between efficacy of drug therapy and adverse events and flora/diversity Bacterial flora analysis in cases with a final diagnosis of non-tumor lesions and its comparison with tumor lesions. Translated with www.DeepL.com/Translator (free version)	—

Measure

Time frame

Success rate of bacterial detection in tissues obtained by EUS-FNB Evaluation of the required sample volume, including area measurement, length, and cell count of EUS-FNB specimens for detection of microbiota by stereomicroscopic observation Association of bacteria flora with pancreatic duct and bile duct stenosis Identification of bacteria or bacterial genes associated with background pancreatic diseases (chronic pancreatic disease, pancreatic lipidosis, pancreatitis, etc.) diagnosed by CT/MRI or biopsy Relationships between other tissues (saliva, feces, intestinal mucosa, digestive juices) and microbiota and diversity in pancreatic tissues. Assessment of the relationship between progression and bacterial flora/diversity in malignant tumors Evaluation of the relationship between response to therapy and microbiota/diversity. Short-term/long-term prognosis and bacterial flora/diversity Assessment of the association between efficacy of drug therapy and adverse events and flora/diversity Bacterial flora analysis in cases with a final diagnosis of non-tumor lesions and its comparison with tumor lesions. Translated with www.DeepL.com/Translator (free version)

—

Countries

Japan

Contacts

Public ContactHonda Takashi

Nagoya University Hospital Department of Gastroenterology and Hepatology

honda@med.nagoya-u.ac.jp0527412111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026