CTE iNPH
Conditions
Interventions
To conduct PET examinations using the following tracers: 18F-SMBT-1
To conduct PET examinations using the following tracers: 11C-PiB
To conduct PET examinations using the following tracers: 18F-flutem
Sponsors
Cyclotron and Radioisotope Center, Tohoku University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: CTE group with positive symptoms: (1) Informed consent by the participant or by the substitues (native Japanese) (2) Ages: basically 30 to 65 years old (3) Fulfilling the conditions of CTE (history of playing contact sports for more than 10 years or traffic accidents etc.) with clear symptoms of CTE (4) Those who can tolerate PET examination of up to 45 mins Possible mild CTE group without positive symptoms: (1) Informed consent by the participant or by the substitues (native Japanese) (2) Ages: basically 30 to 65 years old (3) Fulfilling the conditions of possible CTE (history of playing contact sports for more than 5 years or traffic accidents etc.) without clear symptoms of CTE (4) Those who can tolerate PET examination of up to 45 mins iNPH group with positive symptoms: (1) Informed consent by the participant or by the substitues (native Japanese) (2) Ages: basically 60 to 90 years old (3) Fulfilling the conditions of iNPH and planning shunt operation (4) Those who can tolerate PET examination of up to 45 mins Healthy control (HC) group (1) Informed consent by the participant or by the substitue (native Japanese) (2) Ages: basically 30 to 90 years old (3) Those who can tolerate relatively long PET examination (up to 2 hours)
Exclusion criteria
Exclusion criteria: (1) Administration of irreversible MAO-B inhibitors, Habitual smoking (within 1 year of entry) (2) Being in the period of pregnancy, possible pregnancy, breast feeding, within 28 days after child birth (3) Severe allergic reactions to drugs and foods (4) Psychiatric disorders, which may make the participation to this study difficult (5) Taboo conditions for MRI examinations (cardiac pacemaker, intracorpoporial metals, etc. to be checked with questionnaire in advance) (6) Systemic circulatory and metabolic disorders as well as organ dysfuctions, such as diabetes melitus, hypertension, endocrinolog ical disorders, congestive heart failure, angina petoris, severe renal dysfunctions with Ccr<30mL/min or under plasmapheresis) (7) Past history of malignant diseases within 1 year of entry (8) Any sociomedial conditions, which may make the participation to this study difficult
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SUV ratio (SUVR) | — |
Countries
Japan
Contacts
Public ContactKotaro Hiraoka
Cyclotron and Radioisotope Center, Tohoku University Division of Cyclotron Nuclear Medicine
Outcome results
None listed