Effect of mechanical insufflation-exsufflation on respiratory system compliance and respiratory system resistance in patients with neuromuscular disease using tracheostomy and invasive mechanical ventilation, and factors affecting mechanical insufflation exsufflation-expiratory flows

Effect of mechanical insufflation-exsufflation on respiratory system compliance and respiratory system resistance in patients with neuromuscular disease using tracheostomy and invasive mechanical ventilation, and factors affecting mechanical insufflation exsufflation-expiratory flows - Effect of mechanical insufflation-exsufflation on respiratory system compliance and respiratory system resistance in patients with neuromuscular disease using tracheostomy and invasive mechanical ventilation, and factors affecting mechanical insufflation exsufflation-expiratory flows

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000049437

Enrollment

Registered

2022-11-06

Start date

2019-02-13

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuromuscular disease

Interventions

Mechanical insufflation exsufflation (Set pressures 20, 30, and 40cmH2O)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with neuromuscular disease using tracheostomy and invasive mechanical ventilation

Exclusion criteria

Exclusion criteria: 1)Patients with a history of pneumothorax 2)Patients with progressive lung disease 3)Patients with unstable hemodynamics due to heart failure 4)Patients who have difficulty in measuring respiratory system compliance and respiratory system resistance using a ventilator

Design outcomes

Primary

Measure	Time frame
Respiratory system compliance, respiratory system resistance and mechanical insufflation exsufflation-expiratory flows.	—

Secondary

Measure	Time frame
Plateau pressure, peak inspiratory pressure, mean airway pressure, SpO2, EtCO2, pulse, age, male, height, weight, BMI, disease duration, duration of TMV, biochemical examination of blood, vital capacity, finding from study of images.	—

Countries

Japan

Contacts

Public ContactYoshinobu Sato

National Hospital Organization Iwakuni Clinical Center Department of Rehabilitation

y.sato1214@gmail.com0827-34-1000

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026