Evaluation of combined effects for middle aged female about ingesting food containing amino acids and exercise on facial muscles and features.

Evaluation of combined effects about ingesting food containing amino acids and exercise on facial muscles and features : a randomized, placebo-controlled, double-blind study - Evaluation of combined effects about ingesting food containing amino acids and face exercise on facial muscles and features by RCT study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000049380

Enrollment

Registered

2022-10-31

Start date

2022-10-31

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy adults

Interventions

After daily exercise by facial equipment device, intake food (active) once a day for12 weeks. After daily exercise by facial equipment device, intake of food (placebo) once a day for 12 weeks

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1) Japanese healthy female aged 40-54 years 2) Females who are concerned about sagging face and smile lines 3) Females with a BMI of 20-23.9

Exclusion criteria

Exclusion criteria: (1) Subjects who have a smoking habit. (2) Subjects with a history of serious diseases such as heart, liver, kidneys. (3) Subjects who have 5 or more metal objects (bolts, silver teeth, etc.) on the upper jaw. (4) Subjects with a history of other serious diseases. (5) Subjects who is taking medication or under medical treatment. (6) Subjects who have undergone immunosuppression or other treatment within 3 months. (7) Subjects who may develop allergies related to the study. (8) Subjects with chronic skin diseases such as atopic dermatitis. (9) Subjects who have scars, warts, pimples, permanent makeup, burns, etc. on the face that affect the research target area. (10) Claustrophobic subjects. (11) Subjects receiving "hormone replacement therapy". (12) Subjects who have experience in aesthetic medicine that affect the research target area. (13) Subjects using supplements. (14) Subjects with irregular lifestyle habits such as eating, sleeping and skin care. (15) Subjects drinking heavily. (16) Subjects who can't keep the daily records. (17) Subjects who is planning to get pregnant during the test period after the day of informed consent or is currently pregnant and lactating. (18) Subjects who participate in other clinical trial. (19) Subjects whose family members work for companies related to the sale of beauty equipment and supplements. (20) Subjects judged by the physician to be unsuitable for this study.

Design outcomes

Primary

Measure	Time frame
Change in thickness of the central part and originating part of the zygomaticis major muscle.	—

Secondary

Measure	Time frame
Depth and angle of the laugh lines Angle of the laugh lines from the nose 3D facial photography Skin elasticity	—

Countries

Japan

Contacts

Public ContactIkuko Sasahara

Ajinomoto Co., Inc. Institute of Food Sciences and Technologies

ikuko.sasahara.ve8@asv.ajinomoto.com070-4017-9656

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026