Glaucoma
Conditions
Sponsors
Tohoku University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Disease name:Alzheimer's type dementia, Mild Cognitive Impairment (MCI), cognitively normal subjects (no abnormality in simple dementia tests CADi2, Mini-Cog, MMSE) 2.Stage:early stage 3.Age:50 years old or older, 90 years old or younger (at the time of registration) 4.Gender:Regardless of gender
Exclusion criteria
Exclusion criteria: 1. Decline in cognitive function other than Alzheimer's type dementia (including patients with drug-induced, depression, organic diseases, vascular dementia, metabolic diseases, Lewy body dementia, etc.) 2.Those who have severe dysphagia and have difficulty taking curcumin supplements 3.Alcohol addiction, drug addiction patients 4.Those who cannot follow the protocol of this study such as oral administration and fundus examination due to severe cognitive decline. 5.Those who have been administered corticosteroids within 1 month 6.Those with gallbladder disease, gallstones, gastrointestinal disorders 7.Those who have been diagnosed with angle-closure glaucoma and have difficulty in mydriasis 8.Those who cannot perform visual field test or OCT, those who have difficulty in fundus examination and cannot see through the fundus with SLO 9.Those who have severe vision loss (need assistance in daily life due to visual impairment) 10.Those who are judged by the principal investigator or research coordinator to be unsuitable for participation in the research 11.Pregnant women, lactating women, those who wish to become pregnant during the research period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences between Alzheimer's disease and normal subjects in parameters obtained by retinal amyloid imaging | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of parameters acquired by retinal amyloid imaging with glaucoma complication rate | — |
Countries
Japan
Contacts
Public ContactMakoto Ishikawa
Tohoku University Graduate School of Medicine Department of Ophthalmology
Outcome results
None listed