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Diagnostic study on retinal amyloid deposition and dementia development in glaucoma patients

Diagnostic study on retinal amyloid deposition and dementia development in glaucoma patients - Diagnostic study on retinal amyloid deposition and dementia development in glaucoma patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000049245
Enrollment
250
Registered
2022-10-18
Start date
2022-10-20
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma

Interventions

Sponsors

Tohoku University Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Disease name:Open-angle glaucoma patients, cataract patients 2.Stage:early to middle stage 3.Age:50 years old or older, 85 years old or younger(at the time of registration) 4.Gender:Regardless of gender

Exclusion criteria

Exclusion criteria: 1.Those who have severe dysphagia and have difficulty taking curcumin supplements 2.Alcohol addiction, drug addiction patients 3.Those who cannot follow the protocol of this study such as oral administration and fundus examination due to severe cognitive decline. 4.Those who have been administered corticosteroids within 1 month 5.Those with gallbladder disease, gallstones, gastrointestinal disorders 6.Those who have been diagnosed with angle-closure glaucoma and have difficulty in mydriasis 7.Those who cannot perform visual field test or OCT, those who have difficulty in fundus examination and cannot see through the fundus with SLO 8.Those who have severe vision loss (need assistance in daily life due to visual impairment) 9.Those who are judged by the principal investigator or research coordinator to be unsuitable for participation in the research 10.Pregnant women, lactating women, those who wish to become pregnant during the research period

Design outcomes

Primary

MeasureTime frame
Differences between glaucoma patients, cataract patients and healthy subjects regarding the parameters obtained by retinal amyloid imaging

Secondary

MeasureTime frame
Correlation between parameters acquired by retinal amyloid imaging and cognitive function according to glaucoma severity (glaucoma subgroup analysis)

Countries

Japan

Contacts

Public ContactMakoto Ishikawa

Tohoku University Graduate School of Medicine Department of Ophthalmology

ishikawa-m@oph.med.tohoku.ac.jp022-717-7294

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026