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The incidence of macrophage activation syndrome in patients with adult-onset Still's disease receiving biological therapy

The incidence of macrophage activation syndrome in patients with adult-onset Still's disease receiving biological therapy - The incidence of macrophage activation syndrome in patients with adult-onset Still's disease receiving biological therapy

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000049243
Enrollment
Unknown
Registered
2022-10-17
Start date
2022-10-17
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult-onset Still&#39

Interventions

None listed

Sponsors

Yokohama City University Graduate School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1)The published study including case-control study, cohort study, and randomized clinical trial. (2)The patients are clinically diagnosed with AOSD. (3)The experimental group of the study is treated by biologics, with or without control treatment arm. (5)The study illustrates the safety of biologics. (6)Only full-text papers are used to analyze.

Exclusion criteria

Exclusion criteria: (1)Systematic review or meta-analysis articles. (2)Case reports or case series reporting less than 5 cases. (3)The republished research literature is excluded unless the research includes new findings related to adverse events listed in inclusion criteria. (4)Studies with no or insufficient safety results at the time of the literature search. (5)Studies published in languages other than English.

Design outcomes

Primary

MeasureTime frame
The primary outcome: The prevalence of MAS will be pooled using random effects model meta-analysis.

Secondary

MeasureTime frame
Secondary outcome: The frequency of serious adverse events will be pooled using random effects model meta-analysis.

Countries

Japan

Contacts

Public ContactKaoru Minegishi

Yokohama City University Graduate School of Medicine Department of Stem Cell and Immune Regulation

kaoru_t@yokohama-cu.ac.jp045-787-2630

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026