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Evaluation of the Effect of Remimazolam on Intraoperative Motor Evoked Potential Monitoring - Comparison with Propofol

Evaluation of the Effect of Remimazolam on Intraoperative Motor Evoked Potential Monitoring - Comparison with Propofol - Evaluation of the Effects of Remimazolam on Intraoperative Motor Evoked Potentials

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000049191
Enrollment
60
Registered
2022-10-11
Start date
2023-01-04
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spine Surgery Patients

Interventions

None listed

Sponsors

University of Occupational and Environmental Health, Japan
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Among the patients who underwent spinal surgery and were monitored for MEP (1) ASA-PS1 and 2 patients who are 18 years of age or older (ii) Patients who have given a full explanation of the study and who have given their free and voluntary written consent based on full understanding.

Exclusion criteria

Exclusion criteria: (1) Patients with epileptic seizures or history of epilepsy 2) Patients with muscle disease 3) Patients with peripheral neuropathy (iv) Patients in shock (5) Patients in coma (vi) Patients with a history of drug dependence (g) Patients with hepatic dysfunction

Design outcomes

Primary

MeasureTime frame
Is there a difference in the amplitude and latency of MEP and SEP in the nerve travel area unrelated to the surgical site between general anesthesia with propofol and general anesthesia with remimazolam? Compare the difference between control and final MEP values in each case.

Secondary

MeasureTime frame
Is there a difference between propofol and remimazolam in the time required from the end of anesthetic administration until neurologic findings can be obtained?

Countries

Japan

Contacts

Public ContactKotaro Hamada

University of Occupational and Environmental Health, Japan Department of Anesthesiology

k-hamada@med.uoeh-u.ac.jp0936031611

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026