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Exploratory study to access the relationship between chronic pain and HMGB1

Exploratory study of plasma HMGB1 dynamics in chronic pain patients with different backgrounds - CP-HMGB1 study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000049112
Enrollment
230
Registered
2022-10-04
Start date
2022-10-04
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic pain

Interventions

None listed

Sponsors

Okayama University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients 1) Patients who visit the pain clinic, Department of Anesthesiology, Okayama University Hospital after ethics committee approval to March 31, 2024. 2) Patients who consent to voluntary participate in writing. 3) Patients aged 20 to 90 years at the time of informed consent. Healthy participants 1) Those who have no pain lasting more than 3 months. 2) Those who are able to obtain written consent from the individual to participate in the research voluntarily. 3) Those who are 20 years old or older and under 90 years old at the time of obtaining consent.

Exclusion criteria

Exclusion criteria: 1) Women who are pregnant or may become pregnant 2) Cancer pain 3) Acute cerebral infarction, acute myocardial infarction, cerebral hemorrhage 4) In addition, patients considered to be inappropriate for the study, the study doesn't benefit for participants, the case that plan evaluation is prevented, limited, or confused, participants are family member of employee, principal investigator, or co-investigator, etc.

Design outcomes

Primary

MeasureTime frame
Evaluation of plasma HMGB1 level and pain intensity (VAS/BPI)

Secondary

MeasureTime frame
Plasma levels (oxytocin, cortisol, cystatin C), psychological evaluation (HADS/PCS), EQ-5D (QOL questionnaire)

Countries

Japan

Contacts

Public ContactKyosuke Arakawa

Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Anesthesiology and Resuscitology

pvyw4hhv@s.okayama-u.ac.jp086-235-7330

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026