None (Healthy adults)
Conditions
Interventions
Intakes of test food for 12 weeks
Intakes of placebo food for 12 weeks
Sponsors
Kirin Holdings Company, Limited
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Men and women in good health who are between 45 and 70 years old: Women are limited to postmenopausal (Duration of amenorrhea; >1 y) (2) Subjects whose FMD values of 5.5% >= (3) Subjects whose baPWV values of 1400 cm/sec <= (4) Subjects who have a briefing of the content of the present study, fully understanding and agreeing to its objective and are able to provide a written informed consent.
Exclusion criteria
Exclusion criteria: (1) Subjects who have been diagnosed with heart disease, liver disease, kidney disease, respiratory disease, endocrine disease, metabolic disease, or a history of these diseases (2) Subjects who have the disease under treatment (3) Subjects who regularly use supplements, health food (including foods for specified health use / foods with functional claims) during the test period (4) Subjects who have currently been taking medicines, supplements / health foods or cosmetics with any functional claims such as L-citrulline, L-arginine, L-ornithine, procyanidins, bonito elastin, linolenic acid, DHA, EPA, CoQ10, nattokinase, lutein, blueberries, cassis, vitamin E, ginkgo biloba extract, melilot, polyphenols (hesperidin, flavangenol, pycnogenol etc.) (5) Subjects who have currently been taking medicines, supplements / health foods or cosmetics for the purpose of improving blood flow and blood pressure in addition to the ingredients listed in (4) (6) Subjects who take part in another clinical study during the study, or who have participated as subjects in another clinical trials within the past 3 months (7) Subjects who are excessively take alcohol (expressed in an amount of alcohol: over 20g/day) (8) Subjects who have a smoking habit (those who smoke daily or occasionally in the last 3 months) (9) Subjects who conduct hormone replacement therapy in the 3 months. (10) Asthma patients (11) Subjects who have severe anemia (12) Subjects who have multiple irregularities in their lives during the research period due to day / night shift work or night work, or those who are engaged in physical labor such as transporting heavy objects. (13) Subjects who have been pregnant , or have a plan to breast feed during the study period (14) Subjects who are judged by the investigator to be inappropriate as subjects based on the test results at the time of screening (15) Subjects deemed unsuitable by the investigator for other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vascular function | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective feelings evaluation Blood pressure Blood analysis | — |
Countries
Japan
Contacts
Public ContactMasakazu Tomaru
Synapse Planning Company, Limited. Clinical Trial Session
Outcome results
None listed