Effectiveness of combined exercise program and educational intervention for musculoskeletal symptoms (arthralgia, myalgia, stiffness) caused by hormone therapy

Complex intervention including pain science education and patient-led goal setting based self-management strategies for management of aromatase inhibitor-induced musculoskeletal symptoms: a single-arm feasibility and pilot study - Complex intervention including pain science education and patient-led goal setting based self-management strategies for management of aromatase inhibitor-induced musculoskeletal symptoms: a single-arm feasibility and pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000049035

Enrollment

Registered

2022-10-16

Start date

2023-01-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aromatase inhibitor-induced musculoskeletal symptoms (AIMSS)

Interventions

Combined intervention of pain neuroscience education and goal setting approach 3 months

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: (1) Hormone receptor-positive clinical stage I-III breast cancer (2)Duration of AI treatment for more than 6 months (3)Onset of Pain or Stiffness after AI treatment (4) BPI intensity (worst pain)3 or more in the past week, pain or stiffness lasting more than 3 months (5)Moderate aerobic exercise less than 90 min per week and no strength training twice a week.

Exclusion criteria

Exclusion criteria: (1) Specific pain-related symptoms (neuropathic pain, rheumatic diseases, history of orthopedic surgery, severe osteoarthritis, inflammatory diseases, fibromyalgia) (2) cancer treatment-related pain other than AIMSS with BPI worst pain intensity > 1 in the last week (e.g. post-operative pain, chemotherapy-induced peripheral neuropathy) (3) Recurrence of cancer (4) Restricted from exercising by doctor. (5) Having received form of PNE in the past.

Design outcomes

Primary

Measure	Time frame
Brief Pain Inventory intensity (worst) at 3 months after start	—

Secondary

Measure	Time frame
Disability QOL Central Sensitization Inventory Quantitative Sensory Testing Psychological symptoms	—

Countries

Japan

Contacts

Public ContactMasahiro Manfuku

Breast Care Sensyu Clinic Department of Rehabilitation

sunday_attinente@yahoo.co.jp072-430-0811

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026