Hepatocellular carcinoma
Conditions
Interventions
1) Abdominal ultrasonography at 3 and 9 months after radiotherapy 2) Contrast-enhanced CT/MRI at 6 and 12 months after radiotherapy 3) Evaluation of tumor markers at 3, 6, 9 and 12 months after radi
Sponsors
Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Age 18 years or higher 2) Histologically or radiologically diagnosed hepatocellular carcinoma 3) Tumor number 3 or less; tumor size 5 cm or less 4) Undergoing SBRT for a single tumor 5) Well visualized by non-contrast ultrasonography 6) Informed consent obtained
Exclusion criteria
Exclusion criteria: 1) Three months or longer duration between pretreatment radiological evaluation and SBRT 2) Apparent vascular invasion and/or metastasis 3) Unable to perform contrast-enhanced CT/MRI 4) Other diseases requiring more frequent contrast-enhanced CT/MRI 5) Considered not appropriate as a participant of this study by investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The frequency of addition of contrast-enhanced CT/MRI at 3 or 9 momths after radiotherapy | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Reasons for addition of contrast-enhanced CT/MRI 2) Tumor detection rates at 3 and 9 months by ultrasonography 3) Tumor detection rates at 6 and 12 months by contrast-enhanced CT/MRI 4) Local control rates at 3, 6, 9 and 12 months 5) Time to local progression 6) Overall survival 7) Adverse events due to contrast agents 8) Total number of contrast-enhanced CT/MRI during follow-up period | — |
Countries
Japan
Contacts
Public ContactMasayuki Ueno
Kurashiki Central Hospital Department of Gastroenterology and Hepatology
Outcome results
None listed