Healthy adults
Conditions
Interventions
After the 1-week observation period, participants will consume food X for 1 week, food Y for 1 week, and both food X and Y for 3 weeks. The day before the blood collection day, which will be set 5 tim
Sponsors
Yakult Central Institute
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Screening entry criteria; Adults who have a bowel movement almost every day. Selection criteria at screening; Eight subjects each with and without endogenous intestinal bacterial species Z will be randomly selected to participate in subsequent interventions. Subjects who are suspected of being infected with COVID-19 during the subject selection period will be excluded from the selection. Subjects who have taken antibiotics during the selection period will also be excluded, as long as the planned number of subjects is satisfied.
Exclusion criteria
Exclusion criteria: Those who are pregnant or possibly pregnant. Those who are unable to consume the test food due to allergy or other reasons. Those who have taken antibiotics within 1 week prior to the stool sample collection for subject screening. Those with symptoms of suspected COVID-19 infection. Those who have ingested food Y in the past.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiota Fecal organic acids | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood organic acids Amount of food X discharged in stool Bowel habit Body weight Energy expenditure Carbohydrate and lipid metabolism Blood pressure Immunological parameters | — |
Countries
Japan
Contacts
Public ContactYusuke Nagara
Yakult Central Institute Basic Research Department
Outcome results
None listed