Study of effectiveness of oligosaccharide on isoflavone metabolism in gut microbiota

Study of DFA III (difructose anhydride III) on the soy isoflavone metabolism in gut microbiota - Study of DFA III (difructose anhydride III) on the soy isoflavone metabolism in gut microbiota

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000048718

Enrollment

Registered

2022-09-01

Start date

2022-08-05

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adults

Interventions

Take 2.5 g DFA III twice in the morning and evening for 17 days (5 g/day). To analyze soy isoflavone metabolite in urine, subjects drinks 400 mL soy milk (200 mL twice in the morning and evening) for

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Adult male and female over 20 years old 2.Individuals who receive adequate explanation for the purpose and content of this trial and provide written informed consent for participation.

Exclusion criteria

Exclusion criteria: Not applicable

Design outcomes

Primary

Measure	Time frame
The amount of equol in 24-hour urine before and after taking DFA III in 2 weeks	—

Secondary

Measure	Time frame
The equol/daidzein ratio and the amount of isoflavone metabolite in 24-hour urine, Microbiota composition in feces before and after taking DFA III in 2 weeks	—

Countries

Japan

Contacts

Public ContactKyu-Ho Han

Obihiro University of Agriculture and Veterinary Medicine Department of Life and Food Sciences

kyuho@obihiro.ac.jp0155495561

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026