Effect of remimazolam or propofol on the muscle relaxant effect of local anesthetics during general anesthesia

A Comparative Study of the Enhancement of the Muscle Relaxant Effect of Local Anesthetics Used During General Anesthesia Using Remimazolam or Propofol - A Comparative Study of the Enhancement of the Muscle Relaxant Effect of Local Anesthetics Used During General Anesthesia Using Remimazolam or Propofol

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000048574

Enrollment

Registered

2022-08-04

Start date

2022-08-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

jaw deformity

Interventions

In the remimazolam group, the drug is administered intravenously continuously at 12 mg/kg/h according to the package insert, and after the patient becomes unconscious, it is infused continuously at a

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged 18-45 years scheduled for orthognathic jaw surgery under general anesthesia, ASA-PS I

Exclusion criteria

Exclusion criteria: ASA-PS II or higher, emergency surgery, patient or parental consent not obtained, taking benzodiazepines, contraindicated for administration of medications used in this study, or under 18 years of age

Design outcomes

Primary

Measure	Time frame
Using a muscle relaxation monitor, the TOF ratio is recorded every minute for 20 minutes after the administration of local anesthesia and compared.	—

Countries

Japan

Contacts

Public Contactkyotarou koshika

Tokyo dental college Department of Dental Anesthesiology

koshikakyotarou@tdc.ac.jp03-6380-9113

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026