Non-alcoholic fatty liver disease
Conditions
Interventions
None listed
Sponsors
Sapporo Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who are diagnosed with fatty liver in the out-patient clinic or hospitalized at the Department of Gastroenterology, Sapporo Medical University Hospital, and provided written consent. 1. Patients who have already been diagnosed with fatty liver in a medical check-up and are scheduled for an abdominal ultrasound 2. Hospitalized patients who are pointed out with fatty liver by abdominal ultrasound or abdominal CT 3. Patients aged 18 years or older at the time of obtained consent 4. Patients who provided voluntary written consent from the patient or their legal representative after receiving sufficient explanation about participating in this study
Exclusion criteria
Exclusion criteria: 1. Patients with a history diagnosed or treated with heart failure 2. Patients with alcohol intake (ethanol conversion) of 30g/day for males and 20g/day for females 3. Patients diagnosed with liver cirrhosis 4. Patients who have a history of infection or who are treated with hepatitis B or hepatitis C 5. Patients with intrahepatic malignant tumors such as hepatocellular carcinoma 6. Patients with a diagnosis of any malignancy 7. Patients under treatment with steroids, immunosuppressants, anticancer drugs, etc. 8. Patients diagnosed with chronic inflammatory diseases, such as autoimmune hepatitis, inflammatory bowel disease 9. Patients who do not consent to this study 10. Patients who are judged to be inappropriate as research subjects by the research director
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between the degree of hepatic steatosis/fibrosis by abdominal ultrasound and plasma ANP or BNP concentration | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Comparison of the diagnostic accuracy of liver fibrosis between the conventional scoring system to predict liver fibrosis (Fib-4 index, NAFLD fibrosis score) and plasma ANP or BNP concentration 2. Correlation between the presence or absence of arteriosclerosis diagnosed by ABI (ankle brachial pressure index) and plasma ANP/BNP concentrations 3. Correlation between liver fibrosis, arteriosclerosis, and RAS/fibrosis/inflammatory biomarkers | — |
Countries
Japan
Contacts
Public ContactTomoko Ichiki
Sapporo Medical University Department of General Medicine
Outcome results
None listed