A comparative trial between antibiotic combination therapy and steroid therapy for ulcerative colitis patients

A comparative trial between antibiotic combination therapy and steroid therapy for ulcerative colitis patients - A comparative trial between antibiotic combination therapy and steroid therapy for ulcerative colitis patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000048515

Enrollment

350

Registered

2022-07-31

Start date

2008-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ulcerative colitis

Interventions

14 days oral intake of amoxicillin 1500 mg/day, tetracycline 1500 mg/day and metronidazole 750 mg/day

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who has an established diagnosis of UC based on endoscopic, clinical and histological feature

Exclusion criteria

Exclusion criteria: penicillin allergy, administration of antibiotics agents within 2 weeks of study entry, ongoing biologic therapy, pregnancy, cancer and other serious comorbid illness, having stool pathogens including Clostridium difficile, Salmonellae, pathogenic Escherichia coli, etc

Design outcomes

Primary

Measure	Time frame
Remission rate at 3 months	—

Secondary

Measure	Time frame
Response rate at 3 months, remission and response rate at 12 months	—

Countries

Japan

Contacts

Public ContactToshifumi Ohkusa

Juntendo university graduate school of medicine Department of Microbiota Research

ohkusa@juntendo.ac.jp0338133111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026