Japanese Society of Hepato-Biliary-Pancreatic Surgery, Project 09 of Hepatic Surgery National survey of surgical treatment for hepatocellular carcinoma associated with inferior vena cava invasion

Japanese Society of Hepato-Biliary-Pancreatic Surgery, Project 09 of Hepatic Surgery National survey of surgical treatment for hepatocellular carcinoma associated with inferior vena cava invasion - National survey of surgical treatment for hepatocellular carcinoma associated with inferior vena cava invasion

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000048370

Enrollment

150

Registered

2022-07-14

Start date

2019-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular carcinoma

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients who underwent liver resection for HCC with TT in the IVC or RA. This includes cases of HCC with TT in the IVC or RA on pathological diagnosis, even though no TT in the IVC or RA was found in imaging studies before surgery. 2) Cases in which the diagnosis was made by one of the modalities of CT, US, or MRI. 3) Patients who underwent open or laparoscopic resection. 4) Patients and their family members have given full understanding and written consent for participation in clinical research by means of the hospital's comprehensive consent form.

Exclusion criteria

Exclusion criteria: 1) Cases in which only medical treatment (transcatheter arterial chemoembolization, chemotherapy, etc.) was performed and liver resection was not performed. 2) Patients whose preoperative diagnosis was HCC, but the resected specimen showed other neoplastic lesions. 3) Other patients deemed inappropriate by the physician in charge.

Design outcomes

Primary

Measure	Time frame
Outcomes of this study consisted of demographic and preoperative information, type of TT, operative and postoperative information, pathologic information, and recurrence and survival data. The extent of portal vein tumor thrombus (PVTT) and bile duct tumor thrombus (BDTT) were categorized according to the Japanese staging system. In addition to providing the name of the surgical procedure for liver resection, information regarding the surgical method for TT in the IVC or RA, such as concomitant resection of the IVC wall, the use of graft, and the use of cardiopulmonary bypass (CPB) was also recorded. Curative-intent surgery (R0/1 resection) was defined as those with no residual tumor observed macroscopically at the end of the surgery, otherwise considered palliative (R2 resection). Liver failure, bile leakage, and postoperative hemorrhage were recorded using the definition of the International Study Group of Liver Surgery. Other complications were recorded according to the Clavien-Dindo classification. Surgery-related death (complications of grade V) was defined as the death of a patient before discharge.	—

Measure

Time frame

Outcomes of this study consisted of demographic and preoperative information, type of TT, operative and postoperative information, pathologic information, and recurrence and survival data. The extent of portal vein tumor thrombus (PVTT) and bile duct tumor thrombus (BDTT) were categorized according to the Japanese staging system. In addition to providing the name of the surgical procedure for liver resection, information regarding the surgical method for TT in the IVC or RA, such as concomitant resection of the IVC wall, the use of graft, and the use of cardiopulmonary bypass (CPB) was also recorded. Curative-intent surgery (R0/1 resection) was defined as those with no residual tumor observed macroscopically at the end of the surgery, otherwise considered palliative (R2 resection). Liver failure, bile leakage, and postoperative hemorrhage were recorded using the definition of the International Study Group of Liver Surgery. Other complications were recorded according to the Clavien-Dindo classification. Surgery-related death (complications of grade V) was defined as the death of a patient before discharge.

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Countries

Japan

Contacts

Public ContactAkihiko Ichida

The University of Tokyo Hepato-Biliary-Pancreatic Surgery Division

ichida-tky@umin.ac.jp+81-3-3815-5411

Outcome results