Patients aged 65 to 90 years undergoing laparoscopic colorectal cancer surgery
Conditions
Interventions
receive remifentanil infusion guided by SPI (group S) during surgery
receive remifentanil infusion guided by clinical judgement based on hemodynamic parameters (group C) during surgery
Sponsors
Korea University Guro Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who were scheduled to undergo elective laparoscopic colorectal cancer surgery, aged 65 to 90 years, with an American Society of Anesthesiologists (ASA) physical status I to III
Exclusion criteria
Exclusion criteria: history of neuromuscular, neurological, or psychological diseases (dementia, Parkinsons disease, seizure disorders, head injury), abuse of alcohol or illicit drugs or chronic use of psychoactive medication; significant cardiac arrhythmia (atrial fibrillation, or atrioventricular block exceeding 1st degree), and hemodynamically unstable condition before surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intraoperative opioid (remifentanil) consumption | — |
Secondary
| Measure | Time frame |
|---|---|
| intraoperative hemodynamic instability events, awakening time, pain score, fentanyl consumption and incidence of delirium in the post-anesthesia care unit (PACU), and perioperative changes in immunologic markers, including interleukin-6 and natural killer (NK) cell activity | — |
Countries
Asia(except Japan)
Contacts
Public ContactSeok Kyeong Oh
Korea University Guro Hospital Department of Anesthesiology and Pain Medicine
Outcome results
None listed