Comparison of ondansetron and droperidol on prevention of postoperative nausea and vomiting in patients receiving intravenous patient-controlled analgesia after surgery with general anesthesia.

Comparison of ondansetron and droperidol on prevention of postoperative nausea and vomiting in patients receiving intravenous patient-controlled analgesia after surgery with general anesthesia. - Comparison of ondansetron and droperidol on prevention of postoperative nausea and vomiting with iv-PCA.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000048300

Enrollment

180

Registered

2022-07-06

Start date

2022-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative nausea and vomiting after surgery with general anesthesia.

Interventions

We fill 8 mg of ondansetron as an antiemetic and 10 ml of fentanyl as an analgesic in an iv-PCA pump and administer them continuously for 24 hours after surgery. We fill 2.5mg of droperidol as an anti

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing elective surgery under general anesthesia and receiving intravenous patient controlled analgesia after surgery.

Exclusion criteria

Exclusion criteria: Those with hypersensitivity to ondansetron and droperidol, those with severe deterioration of cardiopulmonary / hepato-renal function, those who cannot properly answer postoperative questions.

Design outcomes

Primary

Measure	Time frame
The incidence of nausea and vomiting for 24 hours after surgery of the droperidol group and ondansetron group.	—

Secondary

Measure	Time frame
Non-inferiority of ondansetron to droperidol. Presence or absence of side effects (headache, dizziness, extrapyramidal symptoms, oversedation)	—

Countries

Japan

Contacts

Public ContactHiroshi Yamashita

Kobe city medical center general hospital department of anesthesiology

cantateveritas@kcho.jp0783024321

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026