pregnancy and postpartum period
Conditions
Interventions
None listed
Sponsors
Hamamatsu University Scool of Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Singleton pregnancy women in the third trimester (from 28 to 40 weeks of pregnancy) who are expected vaginal delivery or cesarean section. 1. Pregnant women before the onset of labor (before and after 37 weeks of gestation) 2. Pregnant women during the labor 3. Postpartum women on day 1 postpartum
Exclusion criteria
Exclusion criteria: 1. Patients medicated with antiplatelets or anticoagulants. 2. Patients who have venous thromboembolism. 3. Patients with postpartum hemorrhage during delivery (in vaginal delivery >= 800 mL, in cesarean section >= 1500 mL). 4. Patients complicated with disease involving platelets, coagulation, fibrinolysis, anticoagulation, or antifibrinolysis system. 5. Patients with anemia (hemoglobin concentration <8.0 g/dL) before the delivery. 6. Patients with severe liver disease (or AST >= 100 U/L). 7. Patients with severe renal disease (or serum creatinine >= 1.3 mg/dL).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The parameters of ROTEM assays (CT, CFT, alpha, A10, MCF, LI30, LI60 in NATEM, EXTEM, FIBTEM, and APTEM assays) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Hemoglobin concentration, hematocrit, platelet count, prothrombin time, activated partial thromboplastin time, fibrinogen level, prothrombin fragment 1+2, plasmin alpha2-plasmin inhibitor complex, D-dimer 2) Correlation between ROTEM assays and coagulation/fibrinolysis parameters | — |
Countries
Japan
Contacts
Public ContactChie Fukuchi
Hamamatsu University School of Medicine Department of Obstetrics and Gynecology
Outcome results
None listed