myocardial injury after noncardiac surgery
Conditions
Interventions
a combination of upper body elebation and high flow nasal cannula
a combination of supine and oxygen therapy
Sponsors
Chiba University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients undergoing major thoracic or abdominal surgery under general anesthesia combined with thoracic epidural anesthesia who have at least more than 3 risk factors for Myocardial Injury after Non-cardiac Surgery such as older than 75 years, male, atrial fibrillation, diabetes, hypertension, cardiac failure (history), coronary artery disease, peripheral vascular disease, renal dysfunction (eGFR<60), and stroke.
Exclusion criteria
Exclusion criteria: 1. emergency surgery 2. palliative operation 3. severe renal dysfunction (eGFR<15 or dialysis patients) 4. severe respiratory disease with hypoxemia and/or hypercapnia 5. oxygen therapy before surgery 6. unable to accept high-flow nasal cannula therapy 7. renal and ureteral surgery 8. sepsis 9. use of antimicrobials before surgery 10. pulmonary embolism 11. preoperative high-sensitivity troponin T levels greater than or equal to0.065 ng/mL 12. difficulty of obtaining concents from the patient 13. judged by the principal investigator to be inappropriate as a participant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| maximum difference of high-sensitivity troponin T before and after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of Myocardial Injury after Non-cardiac Surgery, incidence of high-sensitivity troponin T greater than 0.005 ng/mL, major postoperative complications within 30 days after surgery, | — |
Countries
Japan
Contacts
Public ContactYoshihiro Yamaji
Graduate School of Medicine, Chiba University Department of Anesthesiology
Outcome results
None listed