alcoholic liver injury
Conditions
Interventions
None listed
Sponsors
Nara medical university Hospital Department of Gastroenterology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. patients whose eligibility for treatment with nalmefene has been determined as the best treatment in the usual course of practice 2. patients between 20 and 80 years of age, regardless of gender 3. patients who have been diagnosed by a physician who has taken the training required of physicians when calculating the additional fee for inpatient medical management of severe alcoholism or the "e-learning training on the diagnosis and treatment of alcoholism" organized by the Japanese Society of Alcoholism and Alcohol Abuse Medicine and the Japanese Society of Hepatology. Patients with alcoholic liver disease (hepatic reserve of less than 10 points in Child-Pugh score) 4. 4. patients with a drinking risk level (DRL) of high or very high for more than 2 weeks 5. patients willing to receive ongoing psychosocial supportive therapy focused on treatment compliance and alcohol consumption reduction
Exclusion criteria
Exclusion criteria: 1. patients under 19 years old and over 80 years old 2. patients with physical withdrawal symptoms 3. Patients with cancer 4. Pregnant and lactating patients 5. patients using opioids other than nalmefene 6. Patients with severely impaired renal function (eGFR<30 ml/min/1.73m2) 7. Patients who have indicated their refusal to participate in the study 8. dementia (PS2 or higher) 9. patients with psychosis other than alcohol use dependence, who are regularly attending or being hospitalized by a neuropsychiatrist, and who are considered to be difficult to participate in the study 10. other patients who are judged to be ineligible by the investigators and subinvestigators of this study 11. Patients with other addictions 12. patients with intellectual disabilities 13. patients with cerebral organic mental disorder 14. patients with a history of taking Nalmefene (Nalmefene reinstatement) 15. patients with a history of treatment for alcohol dependence at a medical institution specializing in addiction 16. patients with psychiatric disorders other than alcohol dependence
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver reserve capacity at each time point. | — |
Secondary
| Measure | Time frame |
|---|---|
| Various blood biochemical indices related to liver injury (continuous variables) | — |
Countries
Japan
Contacts
Public ContactTadashi Namisaki
Nara medical university Hospital Department of Gastroenterology
Outcome results
None listed