Healthy Adult
Conditions
Sponsors
Hokkaido Information University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Subjects who agree to participate in this study with a written informed consent. 2. Japanese males and postmenopausal females between 40 and 65 years old. 3. Subjects whose FMD values are relatively low.
Exclusion criteria
Exclusion criteria: 1. Subjects with difficulty measuring flow- mediated dilation. 2. Subjects whose BMI is >=30 kg/m2. 3. Subjects who are under physician's advice, treatment, and/or medication for hypertension, dyslipidemia and/or diabetes. 4. Subjects with implantable electronic medical devices. 5. Subjects with serious cerebrovascular, cardiac, hepatic, renal, gastrointestinal diseases, and/or affected with infectious diseases requiring reports to the authorities. 6. Subjects with major surgical history relevant to the digestive system such as gastrectomy, gastrorrhaphy, enterectomy, etc. 7. Subjects with unusually high and/or low blood pressure and/or abnormal hematological data. 8. Subjects with severe anemia. 9. Pre- or post-menopausal women complaining of obvious physical changes. 10. Subjects who are at risk of having allergic reactions to drugs or foods. 11. Subjects who regularly take medicine, functional foods, and/or supplements which would affect blood vessel function and/or blood pressure. 12. Smokers, alcohol addicts or subjects with disordered lifestyle. 13. Subjects who donated either 400 ml whole blood within 16 wks (women), 12 wks (men), 200 ml whole blood within 4 wks, or blood components within 2 wks, prior to this study. 14. Pregnant or lactating women or women who expect to be pregnant. 15. Subjects who currently participate in other clinical trials, or participated within the last 4 wks prior to this study. 16. Any other medical and/or health reasons unfavorable to participation in this study, as judged by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Flow-mediated dilation | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep and stress questionnaires, home blood pressure | — |
Countries
Japan
Contacts
Public ContactNaoyuki HONMA
Hokkaido Information University Health Information Science Center
Outcome results
None listed