Understaning of mechanisms in coping with grief after bereavement

Elucidation of biological mechanisms of pathological grief in a longitudinal investigation - Biological mechanisms of grief

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000047781

Enrollment

Registered

2022-05-17

Start date

2022-05-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prolonged grief disorder

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Aged 20 years or older 2) Bereaved of a significant other (a family member, relative, friend, or partner) 3) Bereaved for more than 12 months 4) Capable to provide informed consent 5) MRI indicated

Exclusion criteria

Exclusion criteria: 1) Any psychiatric disorders excluding prolonged grief disorder, depressive disorders, posttraumatic stress disorder, or anxiety disorders 2) Substance-related disorders within 6 months 3) Self-harm or suicide attempt within 6 months 4) A score less than 24 on Mini-Mental State Examination 5) Neurological disorders 6) Pregnancy

Design outcomes

Primary

Measure	Time frame
Brain functional and structural imaging measures	—

Secondary

Measure	Time frame
Salivary inflammatory markers, salivary oxytocin concentration, oxytocin receptor DNA methylation polymorphism, heart rate variability, physical activity, grief symptoms, depression symptoms, anxiety symptoms, posttraumatic stress symptoms, quality of life, sleep quality, daytime sleepiness, pain empathy, attachment style, post-traumatic growth	—

Countries

Japan

Contacts

Public ContactTakuya Yoshiike

National Center of Neurology and Psychiatry Department of Sleep-Wake Disorders, National Institute of Mental Health

yoshiike@ncnp.go.jp042-346-2071

Outcome results