FindTrial
Sign In

Investigation of the association between proton pump inhibitors and risk of adverse drug reactions using the Japanese medical database.

Investigation of the association between proton pump inhibitors and risk of adverse drug reactions using the Japanese medical database. - Investigation of the association between proton pump inhibitors and risk of adverse drug reactions using the Japanese medical database.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000047771
Enrollment
Unknown
Registered
2022-05-17
Start date
2022-01-11
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

drug-induced renal dysfunction

Interventions

None listed

Sponsors

Department of Hospital pharmacy Hamamatsu University School of Medicine
Lead Sponsor
University of Shizuoka
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients started on regular prescriptions (more than 1 month) for PPIs or H2 blockers

Exclusion criteria

Exclusion criteria: Patients diagnosed with an adverse effect disease within 1 year prior to the index date when they started taking PPIs and H2 blockers

Design outcomes

Primary

MeasureTime frame
chronic kidney disease—

Secondary

MeasureTime frame
Adverse events such as acute interstitial nephritis (AIN), Clostridioides difficile enteritis Changes in the onset of adverse effects with the type and dose of PPIs and H2 blockers Changes in the incidence of adverse effects in each group by propensity score matching—

Countries

Japan

Contacts

Public ContactHironari Tanaka

Hamamatsu University School of Medicine Department of Hospital pharmacy

htanaka@hama-med.ac.jp053-435-2767

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026